4.4 Article

Smart combination of β-cyclodextrin polymer-conjugated magnetic nanosorbent for potential adsorption of deoxyribonucleic acid

Journal

SEPARATION SCIENCE AND TECHNOLOGY
Volume 54, Issue 6, Pages 902-915

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1080/01496395.2018.1524485

Keywords

beta-Cyclodextrin; adsorption; magnetic nanoparticles; biomedical application; inclusion complex

Funding

  1. Research University Grant, Universiti Sains Malaysia [RUI: 1001/CIPPT/811322]
  2. Fundamental Research Grant Scheme, Ministry of Higher Education (MOHE), Malaysia [FRGS: 203/CIPPT/6711557]

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We reported the synthesis and characterization of Fe3O4 magnetic nanoparticles modified beta-cyclodextrin polymer (MNP@beta CD-TDI) for the adsorption of deoxyribonucleic acid (DNA). The synthesized MNP@beta CD-TDI was characterized by Fourier Transform Infra-Red spectroscopy and Vibrating Sample Magnetometer. Experiments were performed in a batch mode and parameters that affected the DNA adsorption were investigated. An evaluation of the adsorption behavior revealed that Freundlich model and pseudo-second-order fit the equilibrium data. The adsorption efficiency of DNA was found to be at after being recycled three times. This study could be used as a general platform for future work on DNA adsorption and enrichment.

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