Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume 1851, Issue 6, Pages 824-831Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2014.10.011
Keywords
Phosphoinositide; Cortical actin; Adhesion energy; Membrane tension; Cell migration
Funding
- Japan Society for the Promotion of Science [25440085, 24570216]
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [24113715]
- Uehara Memorial Foundation
- Hyogo Science and Technology Association
- Grants-in-Aid for Scientific Research [25440085, 24113715, 24570216] Funding Source: KAKEN
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In order for the cell to function well within a multicellular system, the mechanical properties of the plasma membrane need to meet two different requirements: cell shape maintenance and rearrangement. To achieve these goals, phosphoinositides play key roles in the regulation of the cortical actin cytoskeleton. PI(4,5)P-2 is the most abundant phosphoinositide species in the plasma membrane. It maintains cell shape by linking the actin cortex to the membrane via interactions with Ezrin/Radixin/Moesin (ERM) proteins and class I myosins. Although the role of D3-phosphoinositides, such as PI(3,4,5)P-3, in actin-driven cell migration has been a subject of controversy, it becomes evident that the dynamic turnover of the phosphoinositide by the action of metabolizing enzymes, such as 5-phosphatases, is necessary. Recent studies have revealed an important role of PI(3,4)P-2 in podosome/invadopodia formation, shedding new light on the actin-based organization of membrane structures regulated by phosphoinositide signaling. This article is part of a Special Issue entitled Phosphoinositides. (C) 2014 Elsevier B.V. All rights reserved.
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