Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume 1851, Issue 8, Pages 999-1005Publisher
ELSEVIER
DOI: 10.1016/j.bbalip.2014.12.016
Keywords
Glia; Oligodendrocytes; Axons; Myelin; Lipids
Funding
- German Research Foundation [SI 746/9-1, 10-1, TRR43]
- GIF
- Tschira-Stiftung
- E-Rare program (BMBF)
- Boehringer-Ingelheim-Fonds
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Rapid conduction of nerve impulses requires coating of axons by myelin sheaths, which are lipid-rich and multilamellar membrane stacks. The lipid composition of myelin varies significantly from other biological membranes. Studies in mutant mice targeting various lipid biosynthesis pathways have shown that myelinating glia have a remarkable capacity to compensate the lack of individual lipids. However, compensation fails when it comes to maintaining long-term stability of myelin. Here, we summarize how lipids function in myelin biogenesis, axon-glia communication and in supporting long-term maintenance of myelin. We postulate that change in myelin lipid composition might be relevant for our understanding of aging and demyelinating diseases. This article is part of a Special Issue titled Brain Lipids. (c) 2015 Elsevier B.V. All rights reserved.
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