Journal
RNA BIOLOGY
Volume 16, Issue 2, Pages 155-159Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15476286.2018.1564617
Keywords
Hnrnps; introns; cryptic splicing; transcriptome integrity
Categories
Funding
- Natural Sciences and Engineering Research Council of Canada [RGPIN-2016-06004]
- Manitoba Research Chair Fund
- University of Manitoba Graduate Fellowship
- Research Manitoba
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The family of heterogeneous ribonucleoproteins (hnRNPs) have multiple functions in RNA metabolism. In recent years, several hnRNPs have also been shown to be essential for the maintenance of transcriptome integrity, by preventing intronic cryptic splicing signals from mis-splicing of many endogeneous pre-mRNA transcripts. Here we discuss the possibility for a general role of this family of proteins and their expansion in transcriptome protection.
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