Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume 1851, Issue 1, Pages 51-60Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2014.08.011
Keywords
Myelin lipids; Myelin proteins; Nervous system; Transgenic models; Neuroprotection
Funding
- Giovanni Armenise-Harvard Foundation Career Development Grant
- Fondazione Cariplo [2012-0547, 2008-2511]
- European Commission [FP6 LSHM-CT2006-037498-SOUTH, FP7 602757-HUMAN, PITN-GA-2013-606806-NR-NET]
- Italian Ministry of Education, Universities and Research [2009-K7R7NA, 2008-ZTN724]
- Research Center for the Characterization and Safety Use of Natural Compounds - Giovanni Galli
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Lipids in the nervous system accomplish a great number of key functions, from synaptogenesis to impulse conduction, and more. Most of the lipids of the nervous system are localized in myelin sheaths. It has long been known that myelin structure and brain homeostasis rely on specific lipid-protein interactions and on specific cell-to-cell signaling. In more recent years, the growing advances in large-scale technologies and genetically modified animal models have provided valuable insights into the role of lipids in the nervous system. Key findings recently emerged in these areas are here summarized. In addition, we briefly discuss how this new knowledge can open novel approaches for the treatment of diseases associated with alteration of lipid metabolism/homeostasis in the nervous system. This article is part of a Special Issue entitled Linking transcription to physiology in lipidomics. (C) 2014 Elsevier B.V. All rights reserved.
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