Journal
REPRODUCTIVE TOXICOLOGY
Volume 82, Issue -, Pages 111-123Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2018.10.001
Keywords
2-hydroxy-4-methoxybenzophenone (HMB); Prostate; Testis; Rats; Gene expression profiling; Prenatal and lactational exposure; Mitochondria
Categories
Funding
- NCTR [E0750301]
- FDA/NCTR [FDA 224-12-0003, NIH AES12013]
- NIEHS/NTP [FDA 224-12-0003, NIH AES12013]
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2-hydroxy-4-methoxybenzophenone (HMB) is an ultraviolet light-absorbing compound that is used in sunscreens, cosmetics and plastics. HMB has been reported to have weak estrogenic activity by in vivo and in vitro studies, making it a chemical with potential reproductive concern. To explore if prenatal and lactational I-HMB exposure alters gene expression profiles of the developing reproductive organs, we performed microarray analysis using the prostate and testis of postnatal day (PND) 30 male Sprague-Dawley rats offspring exposed to 0, 3000, or 30,000 ppm of HMB from gestational day 6 through PND 21. Gene expression profiles of the prostate and testis were differentially affected by HMB dose with significant alterations observed at the 30,000 ppm HMB group. Tissue-specific gene expression was also identified. These genes, whose expression was altered by HMB exposure, may be considered as candidate biomarker(s) for testicular or prostatic toxicity; however, further studies are necessary to explore this potential.
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