Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Volume 1850, Issue 1, Pages 186-235Publisher
ELSEVIER
DOI: 10.1016/j.bbagen.2014.03.016
Keywords
Conformer; Crystallography; Dendrimer; Glycan; Lectin; Neoglycoconjugate
Categories
Funding
- Charles University [PRVOUK27]
- European Regional Development Fund [CZ.1.05/1.1.00/02.0109]
- Grant Agency of the Ministry of Health of the Czech Republic [NT13488]
- Spanish Ministerio de Ciencia e Innovacion [BFU2009-10052, CSD2009-00088, BFU2011-24615, BFU2012-36825]
- CIBER de Enfermedades Respiratorias (CIBERES)
- initiative of the Instituto de Salud Carlos III (ISCIII)
- EC research program GlycoHIT [260600]
- ITN network GLYCOPHARM [317297]
- NSERC (Canada)
- Program Molecular and Cell Biology of RAS Presidium
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Background: The most demanding challenge in research on molecular aspects within the flow of biological information is posed by the complex carbohydrates (glycan part of cellular glycoconjugates). How the 'message' encoded in carbohydrate 'letters' is 'read' and 'translated' can only be unraveled by interdisciplinary efforts. Scope of review: This review provides a didactic step-by-step survey of the concept of the sugar code and the way strategic combination of experimental approaches characterizes structure function relationships, with resources for teaching. Major conclusions: The unsurpassed coding capacity of glycans is an ideal platform for generating a broad range of molecular 'messages'. Structural and functional analyses of complex carbohydrates have been made possible by advances in chemical synthesis, rendering production of oligosaccharides, glycoclusters and neoglycoconjugates possible. This availability facilitates to test the glycans as ligands for natural sugar receptors (lectins). Their interaction is a means to turn sugar-encoded information into cellular effects. Glycan/lectin structures and their spatial modes of presentation underlie the exquisite specificity of the endogenous lectins in counterreceptor selection, that is, to home in on certain cellular glycoproteins or glycolipids. General significance: Understanding how sugar-encoded 'messages' are 'read' and 'translated' by lectins provides insights into fundamental mechanisms of life, with potential for medical applications. (C) 2014 Elsevier B.V. All rights reserved.
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