Journal
PTERIDINES
Volume 29, Issue 1, Pages 124-163Publisher
DE GRUYTER POLAND SP Z O O
DOI: 10.1515/pteridines-2018-0013
Keywords
Periodontitis; metabolic syndrome; cardiovascular disease; mental illness; inflammation
Categories
Funding
- Mid-Atlantic Nutrition Obesity Research Center Pilot NORC grant [P30 DK072488]
- Rocky Mountain MIRECC, Denver Colorado
- Military and Veteran Microbiome Consortium for Research and Education (MVM-CoRE), Denver, CO.
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Previous evidence connects periodontal disease, a modifiable condition affecting a majority of Americans, with metabolic and cardiovascular morbidity and mortality. This review focuses on the likely mediation of these associations by immune activation and their potential interactions with mental illness. Future longitudinal, and ideally interventional studies, should focus on reciprocal interactions and cascading effects, as well as points for effective preventative and therapeutic interventions across diagnostic domains to reduce morbidity, mortality and improve quality of life.
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