Journal
PSYCHIATRY RESEARCH
Volume 271, Issue -, Pages 325-327Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2018.12.001
Keywords
Gluten antibodies; HLA; Schizophrenia
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Funding
- Schizophrenia Association of Great Britain, Bangor, UK
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It has been suggested that gluten consumption is linked to schizophrenia, with this link strengthened through the presence of circulating anti-native gliadin antibodies (AGAs). The human leukocyte antigen (HLA) system is crucial for antigen presentation and antibody secretion but no study has examined the relationship between HLA-II variants and circulating antibodies against gliadin peptides. In this study, HLA-II variants were genotyped in patients with schizophrenia and the relationship between these variants and plasma AGA levels was examined. Although there was no association found, HLA-AGA associations could potentially serve as a marker of gluten sensitivity in patients with schizophrenia.
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