Journal
ACTA DERMATO-VENEREOLOGICA
Volume 96, Issue 7, Pages 894-898Publisher
ACTA DERMATO-VENEREOLOGICA
DOI: 10.2340/00015555-2417
Keywords
CTCL; skin; pruritus; IL-31; IL-31RA; OSMR beta
Categories
Ask authors/readers for more resources
Approximately 88% of cutaneous T-cell lymphoma (CTCL) patients are affected by pruritus that responds poorly to current antipruritic therapies. Interleukin (IL)-31, a Th2 cytokine, has been found to be increased in the serum of CTCL patients and to correlate with itch severity. This study investigated the role of IL-31 and its receptors (IL-31 receptor-alpha [IL-31RA] and OSMR beta) in the skin of CTCL patients with mild versus moderate/severe pruritus. Expression levels of IL31, IL-31RA, and OSMR beta in the skin were measured using immunohistochemistry and correlated to pruritus severity and disease stage. In CTCL patients with moderate/severe pruritus, IL-31 was significantly elevated in the epidermis and dermal infiltrate, while IL-31RA and OSMR beta were significantly elevated only in the epidermis. Furthermore, epidermal IL-31 levels correlated to itch severity. These results show that IL-31 may play a role in CTCL pruritus by exerting indirect effects on sensory nerves through epidermal neoplastic T cells and keratinocytes to transmit itch.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available