Journal
PROTEOMICS
Volume 19, Issue 4, Pages -Publisher
WILEY
DOI: 10.1002/pmic.201800353
Keywords
bioenergetics; metabolite profiling; metabolomics; mitochondrial metabolism; tumorigenesis; uncoupling protein 2
Funding
- RCSIRM UKy [1U24DK097215-01A1]
- NCI, National Institutes of Health, Cancer Center Support Grant [P30 CA177558]
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Uncoupling protein 2 (UCP2) is often upregulated in cancer cells. The UCP2 upregulation is positively correlated with enhanced proliferation, tumorigenesis, and metabolic alterations, thus suggesting that UCP2 upregulation can play a key role in sensing metabolic changes to promote tumorigenesis. To determine the global metabolic impact of UCP2 upregulation, C-13(6) glucose as a source molecule is used to trace the metabolic fate of carbon atoms derived from glucose. UCP2 overexpression in skin epidermal cells enhances the incorporation of C-13 label to pyruvate, tricarboxylic acid cycle intermediates, nucleotides, and amino acids, suggesting that UCP2 upregulation reprograms cellular metabolism toward macromolecule synthesis. To the best of our knowledge, this is the first study to bring to light the overall metabolic differences caused by UCP2 upregulation.
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