Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 115, Issue 42, Pages 10582-10587Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1808829115
Keywords
cell wrapping; metal-organic frameworks; anaerobic bacteria; artificial photosynthesis; reactive oxygen species
Categories
Funding
- NASA, Center for the Utilization of Biological Engineering in Space [NNX17AJ31G]
- Suzhou Industry Park Fellowship
Ask authors/readers for more resources
We report a strategy to uniformly wrap Morella thermoacetica bacteria with a metal- organic framework (MOF) monolayer of nanometer thickness for cytoprotection in artificial photosynthesis. The catalytic activity of the MOF enclosure toward decomposition of reactive oxygen species (ROS) reduces the death of strictly anaerobic bacteria by fivefold in the presence of 21% O-2, and enables the cytoprotected bacteria to continuously produce acetate from CO2 fixation under oxidative stress. The high definition of the MOF-bacteria interface involving direct bonding between phosphate units on the cell surface and zirconium clusters on MOF monolayer, provides for enhancement of life throughout reproduction. The dynamic nature of the MOF wrapping allows for cell elongation and separation, including spontaneous covering of the newly grown cell surface. The open-metal sites on the zirconium clusters lead to 600 times more efficient ROS decomposition compared with zirconia nanoparticles.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available