Journal
PLOS ONE
Volume 13, Issue 12, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0207881
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Funding
- Nanolane company (Le Mans)
- Solvay company (Bordeaux)
- Alveole company (Paris)
- C-Nano PACA Network
- Labex INFORM network
- Centuri network
- ANR Recrute grant
- European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant [713750]
- Regional Council of Provence- Alpes-Cote d'Azur
- A*MIDEX - Investissements d'Avenir project [ANR-11-IDEX-0001-02]
- French Government
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Macroscopic properties of physical and biological processes like friction, wetting, and adhesion or cell migration are controlled by interfacial properties at the nanoscopic scale. In an attempt to bridge simultaneously investigations at different scales, we demonstrate here how optical microscopy in Wet-Surface Ellipsometric Enhanced Contrast (Wet-SEEC) mode offers imaging and measurement of thin films at solid/liquid interfaces in the range 1-500 nm with lateral optical resolution. A live, label-free and noninvasive methodology integrated with microfluidic devices allowed here characterization of polymers and proteins patterns together with corresponding phenotypes of living cells.
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