Journal
PLANTA MEDICA
Volume 85, Issue 6, Pages 444-452Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/a-0828-9831
Keywords
Garcinia bracteata; Clusiaceae; prenylated xanthones; cytotoxicity
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Funding
- National Natural Science Foundation of China [81602990]
- Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
- Foundation of Shanghai University of Traditional Chinese Medicine [2016YSN06]
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Six new prenylated xanthones (1-6) and seventeen known xanthones were isolated from extracts of Garcinia bracteata leaves. Their structures were determined by extensive NMR and MS spectroscopic data analysis. The inhibitory activities of the isolates were assayed on HeLa, A549, PC-3, HT-29, and WPMY-1 cell lines. Compounds 1 and 15-17 showed moderate inhibitory effects on tumor cell growth, with IC(50)s ranging from 3.7 to 14.7 mu M.
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