Journal
PLANT CELL
Volume 31, Issue 2, Pages 502-519Publisher
OXFORD UNIV PRESS INC
DOI: 10.1105/tpc.18.00857
Keywords
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Funding
- Danish National Research Foundation (Danmarks Grundforskningsfond) [99]
- National Science Foundation (NSF) [IOS 1339125, MCB 1330337, IOS 1021861]
- USDA National Institute of Food and Agriculture (NIFA), Hatch project [CA-D-PLS-7033-H]
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Although the impacts of crop domestication on specialist pathogens are well known, less is known about the interaction of crop variation and generalist pathogens. To study how genetic variation within a crop affects plant resistance to generalist pathogens, we infected a collection of wild and domesticated tomato accessions with a genetically diverse population of the generalist pathogen Botrytis cinerea. We quantified variation in lesion size of 97 B. cinerea genotypes (isolates) on six domesticated tomato genotypes (Solanum lycopersicum) and six wild tomato genotypes (Solanum pimpinellifolium). Lesion size was significantly affected by large effects of the host and pathogen's genotype, with a much smaller contribution of domestication. This pathogen collection also enables genome-wide association mapping of B. cinerea. Genome-wide association mapping of the pathogen showed that virulence is highly polygenic and involves a diversity of mechanisms. Breeding against this pathogen would likely require the use of diverse isolates to capture all possible mechanisms. Critically, we identified a subset of B. cinerea genes where allelic variation was linked to altered virulence against wild versus domesticated tomato, as well as loci that could handle both groups. This generalist pathogen already has a large collection of allelic variation that must be considered when designing a breeding program.
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