Journal
PLACENTA
Volume 72-73, Issue -, Pages 48-52Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2018.10.008
Keywords
Placenta; Trophoblast; BeWo b30 clone; Syncytialization; ABC transporter; SLC transporter; Forskolin; Cell fusion
Funding
- Swiss National Science Foundation [310030_149958]
- National Center of Competence in Research (NCCR) TransCure, University of Bern, Switzerland
- Lindenhof Foundation, Bern, Switzerland
- Swiss National Science Foundation (SNF) [310030_149958] Funding Source: Swiss National Science Foundation (SNF)
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Although placental membrane transporters have an important impact on materno-fetal nutrient transfer, placental cell models are poorly characterized regarding transporter expression. We assessed the mRNA expression of 26 physiologically important solute carriers and ABC transporters in BeWo (b30 clone) and primary human trophoblast cells (PHT) before and after syncytialization. 77% of the transporters showed similar mRNA expression changes between BeWo and PHT after syncytialization. Selected transporters, however, were either lacking in BeWo or showed different trends after syncytialization. In conclusion, BeWo cells generally represent an apt model for transporter studies, but their suitability should be confirmed for each transporter by comparison with PHT.
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