Journal
PHYTOTHERAPY RESEARCH
Volume 33, Issue 4, Pages 976-988Publisher
WILEY
DOI: 10.1002/ptr.6291
Keywords
combined therapy; curcumin; diabetes mellitus; oxidative stress
Categories
Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior [001]
- National Council for Scientific and Technological Development [141998/2012-1]
- Sao Paulo Research Foundation [1998/09152-6]
- Scientific Support and Development Program of School of Pharmaceutical Sciences
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Insulin with natural antioxidants is emerging as a combination treatment for diabetes mellitus that attempts to exert effective glycemic control without adverse effects. The present study aimed to investigate the additive effects on metabolic disturbances, oxidative damage, and antioxidant defenses in streptozotocin-diabetic rats treated with curcumin and a reduced insulin dose. The best results were obtained in the treatment of diabetic rats with 4-U/day insulin; however, the glycemia levels in these rats were lower than those in normal rats, indicating a risk of hypoglycemia. Isolated treatments using curcumin or insulin in a reduced dose (1U/day) decreased glycemia, dyslipidemia, and biomarkers of liver and kidney damage and increased the activity of hepatic antioxidants (superoxide dismutase and glutathione peroxidase), however, only to a lesser extent than 4-U/day insulin, without improvements in catalase activity or plasma lipid peroxidation. Decreases in glycemia, dyslipidemia, and tissue damage markers were more evident in the curcumin+1-U/day insulin treatment than those seen in isolated treatments. The activity of hepatic antioxidants, including catalase, was further increased, and biomarkers of oxidative damage were decreased. Curcumin with a reduced insulin dose appears to be a promising strategy for combating the complications associated with diabetes and oxidative stress.
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