Journal
PHYSIOLOGY
Volume 34, Issue 1, Pages 30-42Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00034.2018
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Funding
- National Institutes of Health [AG-049806, AR-060701]
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR060701] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG049806] Funding Source: NIH RePORTER
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The ribosome is the enzymatic macromolecular machine responsible for protein synthesis. The rates of protein synthesis are primarily dependent on translational efficiency and capacity. Ribosome biogenesis has emerged as an important regulator of skeletal muscle growth and maintenance by altering the translational capacity of the cell. Here, we provide evidence to support a central role for ribosome biogenesis in skeletal muscle growth during postnatal development and in response to resistance exercise training. Furthermore, we discuss the cellular signaling pathways regulating ribosome biogenesis, discuss how myonuclear accretion affects translational capacity, and explore future areas of investigation within the field.
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