Journal
PATHOLOGY
Volume 51, Issue 2, Pages 142-147Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.pathol.2018.10.017
Keywords
HDL; lipids; atherosclerosis; cardiovascular risk; clinical trials
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High-density lipoprotein (HDL) has received increasing interest due to observations of an inverse relationship between its systemic levels and cardiovascular risk and targeted interventions in animal models that have had favourable effects on atherosclerotic plaque. In addition to its pivotal role in reverse cholesterol transport, HDL has been reported to possess a range of functional properties, which may exert a protective influence on inflammation, oxidation, angiogenesis and glucose homeostasis. This has led to the development of a range of HDL targeted therapeutics, which have undergone evaluation in clinical trials. The current state of HDL in cardiovascular prevention will be reviewed.
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