Journal
PAIN
Volume 160, Issue 5, Pages 1019-1028Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/j.pain.0000000000001477
Keywords
Migraine; Pain sensitivity; Conditioned pain modulation; Pressure pain thresholds
Categories
Funding
- Arnold W. Strauss Fellow Award (Cincinnati Childrens' Hospital)
- Clinical and Translational Science Award program (University of Cincinnati) [1UL1TR001425]
- National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health - New England Fund, Technion [R01 NS085391, R01NS101321]
- New England Fund, Technion
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS085391, R01NS101321] Funding Source: NIH RePORTER
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Inhibitory pain modulation has been reported to be deficient in adults across different types of chronic pain, including migraine. To determine whether a similar phenomenon occurs in youth, we performed a quantitative sensory testing investigation in adolescents with migraine (N = 19). These patients were compared to healthy adolescents with (Fam-His; N = 20) or without (Healthy; N = 29) a family history of migraine (eg, first-degree relative with migraine). Subjects were first familiarized with the stimuli and visual analogue rating scales using graded noxious stimuli (0 degrees C, 43-49 degrees C range). These data were used to explore potential pain sensitivity differences between the groups. Pain inhibition was assessed by conditioned pain modulation (CPM), which used both suprathreshold heat pain (heat CPM) and pressure pain thresholds (pressure CPM) as the test stimuli before and during cold-water immersion (8 degrees C). In response to the graded heat stimuli, Fam-His participants reported higher pain intensity ratings compared with patients with migraine, who in turn reported higher pain intensity ratings than the healthy controls (F = 3.6, [df = 2, 459], P = 0.027). For heat and pressure CPM, there was no significant group difference in the magnitude of CPM responses. Thus, adolescents with migraine and healthy adolescents have similar inhibitory pain modulation capability, despite having marked differences in pain sensitivity. Although Fam-His participants are asymptomatic, they demonstrate alterations in pain processing, which may serve as markers for prediction of migraine development.
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