Journal
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
Volume 2019, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2019/4617801
Keywords
-
Categories
Funding
- Hungarian National Research, Development and Innovation Office [NKFIH NK-115461]
- Ministry of Human Capacities (Hungary) [UNKP-17-4]
- European Union
- European Regional Development Fund
- [GINOP-2.3.2-15-2016-00040]
- [EFOP-3.6.2-16-2017-00006]
Ask authors/readers for more resources
Reduction in muscle strength with aging is due to both loss of muscle mass (quantity) and intrinsic force production (quality). Along with decreased functional capacity of the muscle, age-related muscle loss is associated with corresponding comorbidities and healthcare costs. Mitochondrial dysfunction and increased oxidative stress are the central driving forces for age-related skeletal muscle abnormalities. The increased oxidative stress in the aged muscle can lead to altered excitation-contraction coupling and calcium homeostasis. Furthermore, apoptosis-mediated fiber loss, atrophy of the remaining fibers, dysfunction of the satellite cells (muscle stem cells), and concomitant impaired muscle regeneration are also the consequences of increased oxidative stress, leading to a decrease in muscle mass, strength, and function of the aged muscle. Here we summarize the possible effects of oxidative stress in the aged muscle and the benefits of physical activity and antioxidant therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available