Journal
ORGANIC LETTERS
Volume 20, Issue 22, Pages 7341-7344Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b03323
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Funding
- National Natural Science Foundation of China (NSFC) (NNSFC) [81522050, 81773589, 81803397, 41776139]
- National Science and Technology Project of China [2018zx09711001-001]
- CAMS Innovation Fund for Medical Science (CIFMS) [2017-I2M-3-010, 2016-I2M-3-010]
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Purpurolide A (1), an unprecedent sesquiterpene lactone with a rarely encountered 5/5/5 spirocyclic skeleton, along with two new 6/4/5/5 tetracyclic sesquiterpene lactones (2 and 3), were isolated from the cultures of the endophytic fungus Penicillium purpurogenum IMM003. The structures and absolute configurations of 1-3 were established by spectroscopic analysis, single-crystal X-ray diffraction, and calculations of the C-13 NMR and ECD data. Compounds 1-3 showed significant inhibitory activity against pancreatic lipase.
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