Journal
ORGANIC LETTERS
Volume 20, Issue 24, Pages 7807-7810Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b03236
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Funding
- NSFC [31770335, 31370333]
- Chongqing Research Program of Basic Research and Frontier Technology [cstc2017jcyjAX0208]
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Solanaceous medicinal plants produce tropane alkaloids (TAs). We discovered a novel gene from Atropa belladonna, AbPPAR, which encodes a phenylpyruvic acid reductase required for TA biosynthesis. AbPPAR was specifically expressed in root pericycles and endodermis. AbPPAR was shown to catalyze reduction of phenylpyruvic acid to phenyllactic acid, a precursor of TAs. Suppression of AbPPAR disrupted TA biosynthesis through reduction of phenyllactic acid levels. In summary, we identified a novel enzyme involved in TA biosynthesis.
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