Trichothecrotocins A-C, Antiphytopathogenic Agents from Potato Endophytic Fungus Trichothecium crotocinigenum

Two trichothecene sesquiterpenoids, trichothecrotocins A (1) and B (2), and a merosesquiterpenoid racemate, (+/-)-trichothecrotocin C (3), were obtained from potato endophytic fungus Trichothecium crotocinigenum by bioguided isolation. Their structures were elucidated by extensive spectroscopic methods, electronic circular dichroism calculations, and single-crystal X-ray diffraction. Compounds 1 and 2 are trichothecenes possessing new ring systems. Compound 3 possesses a novel 6/6-5/5/5 fused ring system. Compounds 1-3 showed antiphytopathogenic activities with MIC values of 8-128 mu g/mL.