4.8 Article

Catalytic Formal Benzylic C-H Bond Functionalization of 2,5-Dialkylfuran Derivatives with Ferrocenyl Alcohols as Alkylation Reagents

Journal

ORGANIC LETTERS
Volume 21, Issue 3, Pages 627-631

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b03701

Keywords

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Funding

  1. National Natural Science Foundation of China [21702117, 21776148]
  2. Natural Science Foundation of Shandong Province [ZR2017BB005, ZR2016BM07]
  3. Key Research & Development Program of Shandong Province [2018GSF118224]
  4. Talents of High Level Scientific Research Foundation [6631115015, 6631110309, 6651118009]
  5. Central Laboratory of Qingdao Agricultural University

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The inert benzylic C-H bond of pi-electron-rich heteroaromatic 2,5-dialkylfuran derivatives was conveniently functionalized with ferrocenyl alcohols as alkylation reagents under catalytic acidic conditions at room temperature, which features chemo- and regiospecificity, mild and metallic catalyst free conditions, and environmental benignity.

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