Journal
ORGANIC LETTERS
Volume 20, Issue 20, Pages 6349-6353Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b02503
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21432007, 21502145]
- Natural Science Foundation of Hubei Province [2016CFB449]
- Wuhan Morning Light Plan of Youth Science and Technology [2017050304010307]
- Shenzhen Nobel Prize Scientists Laboratory Project [C17213101]
- Fundamental Research Funds for the Central Universities [2042018kf0202]
- Program of Introducing Talents of Discipline to Universities of China (111 Project)
Ask authors/readers for more resources
An iridium-catalyzed highly efficient asymmetric hydrogenation of challenging tetrasubstituted alpha-fluoro-beta-enamino esters was successfully developed using bisphosphine-thiourea (ZhaoPhos) as the ligand, which prepared a series of chiral alpha-fluoro-beta-amino esters containing two adjacent tertiary stereocenters with high yields and excellent diastereoselectivities/enantioselectivities (73%-99% yields, >25:1 dr, 91%-> 99% ee, and turnover number (TON) values up to 8600), and no defluorinate byproduct was detected.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
