Journal
ORGANIC LETTERS
Volume 21, Issue 1, Pages 252-255Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b03686
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Funding
- National Natural Science Foundation of China [21732005]
- National Science and Technology Major Projects for Major New Drugs Innovation and Development [2018ZX09711003-015]
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A synthetic strategy for the catalytic asymmetric total synthesis of (+)-strychnine is disclosed. Key features of this synthesis include an organocatalytic enantioselective Michael addition to establish the chirality of the starting building block, a photoinduced radical cascade reaction to access the Corynanthe alkaloid intermediate, and a bioinspired cascade rearrangement to generate the core of the Strychnos alkaloids.
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