Journal
ORGANIC LETTERS
Volume 21, Issue 1, Pages 320-324Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b03831
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Funding
- FONCYT
- CONICET
- SeCyT
- ECOS-MINCyT [A15E02]
- CNRS-CONICET [248434]
- MESR
- CNRS
- Universite Claude Bernard Lyon 1
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A novel approach for the synthesis of tetracyclic indoles and 7-azaindoles is reported. The strategy involves four steps, with a fast rt intramolecular alpha-arylation of ketones as key step. The reaction was inspected synthetically to achieve the synthesis of 11 novel tetracyclic structures with moderate to very good yields (39-85%). Theoretical combined with experimental studies led us to propose a probable polar mechanism (concerted SNAr).
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