Journal
ORGANIC LETTERS
Volume 21, Issue 1, Pages 27-31Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b03394
Keywords
-
Categories
Funding
- Young Scientists Fund of the National Natural Science Foundation of China [21708020]
- Natural Science Foundation of Jiangsu Provence [BK20170969]
- NSF [CHE-1464744]
Ask authors/readers for more resources
Under photoredox catalysis conditions, the conventional electrophilic reactivity of ketimines is inverted to generate nucleophilic species. As a result, chemoselective cross-electrophile couplings between aldehydes and ketimines are achieved via umpolung reactivity of ketimines to furnish amino alcohols (44 examples with good to excellent yields). To illustrate the utility of the amino alcohol products, 1,2-dihydroindol-3-one-based fluorophores are easily synthesized using the coupling products. Finally, a plausible reaction pathway is discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available