Journal
ORGANIC LETTERS
Volume 20, Issue 20, Pages 6544-6549Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b02868
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Funding
- National Natural Science Foundation of China [21572200]
- Fundamental Research Funds for the Central Universities [2017QNA3013]
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The first iron-catalyzed enantioselective Si-H bond insertion reaction of alpha-diazoesters was developed. A new chiral spiro-bisoxazoline ligand has proven to be an optimal ligand for the asymmetric reaction to give versatile chiral alpha-silyl esters in good yields with high enantioselectivities. The mechanism and detailed stereochemical models for enantioselective induction were elucidated by DFT calculations, suggesting that the reaction proceeds via a concerted quintet transition state.
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