Journal
ORGANIC LETTERS
Volume 21, Issue 3, Pages 660-664Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b03786
Keywords
-
Categories
Funding
- National NSFC [21572223, 21572224, 21602217, 21871252]
- Sichuan Youth Science and Technology Foundation [2016JQ0024]
- Start-up Fund of Chengdu University [2081916044]
Ask authors/readers for more resources
The first organocatalyzed asymmetric dearomative cycloaddition between 2-nitrobenzofurans and isatin-derived Morita-Baylis-Hillman carbonates has been developed. Using a modified cinchona alkaloid as the catalyst, a series of structurally diverse cyclopenta[b]benzofuran derivatives with three contiguous stereocenters, including a spiro-quaternary chiral center, could be smoothly obtained in excellent results (all cases >20:1 dr, up to 99% yield and 98% ee). The utility of this method was showcased by the versatile transformations of the product.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available