Journal
OPHTHALMOLOGY
Volume 126, Issue 3, Pages 393-406Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ophtha.2018.09.045
Keywords
-
Categories
Funding
- European Union's Horizon 2020 research and innovation programme [634479]
- Laboratoires Thea (Clermont-Ferrand, France)
- Fondation Voir et Entendre (Paris, France)
- Caisse Nationale de Solidarite pour l'Autonomie (Paris, France)
- AIBILI - Novartis Pharma AG
- Medical Research Council [MC_PC_13048, G1000143]
- Cancer Research UK [C864/A14136]
- Research into Ageing [262]
- Moorfields Eye Charity fellowship
- Richard Desmond Charitable Trust
- Department for Health through National Institute for Health Research
- Landelijke Stiching voor Blinden en Slechtzienden
- Stichting Blindenhulp, Stichting A. F. Deutman Oogheelkunde Researchfonds
- Netherlands Organization for Scientific Research (Vidi Innovational Research Award) [016.096.309]
- European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013) [310644 MACULA]
- Inter-regional grant (Programme Hospitalier de Recherche Clinique [PHRC])
- Regional Council of Burgundy
- CNRS
- Universite de Bourgogne, Regional Council of Burgundy France (PARI Agrale 1)
- FEDER (European Funding for Regional Economic Development)
- French Government grant [ANR-11-LABX-0021-01-LipSTIC Labex]
- Institut National de la Sante et de la Recherche Medicale (Inserm), Paris, France
- Fondation de France
- Fondation pour la Recherche Medicale, Paris
- Region Languedoc-Roussillon, Montpellier, France
- Rhones Poulenc
- Horiba ABX Montpellier
- Research Institute for Diseases in the Elderly (RIDE)
- Ministry of Education, Culture and Science
- Ministry for Health, Welfare and Sports, the European Commission (DG XII)
- Municipality of Rotterdam
- Oogfonds
- Landelijke Stichting voor Blinden en Slechtzienden
- Novartis Foundation
- Netherlands Organisation of Scientific Research (Nederlandse Organisatie voor Wetenschappelijk Onderzoek [NWO]) Investments [175.010.2005.011, 911-03-012]
- Genetic Laboratory of the Department of Internal Medicine, Erasmus Medical Center
- Research Institute for Diseases in the Elderly [014-93-015]
- Netherlands Genomics Initiative/Netherlands Organisation for Scientific Research/Netherlands Consortium for Healthy Aging [050-060-810]
- MaculaFonds
- INRA
- Department of Epidemiology of Ageing, Paris
- Association Retina-France, Toulouse
- Essilor
- Specia
- Centre de Recherche et d'Information Nutritionnelle, Paris
- Erasmus Medical Center and Erasmus University, Rotterdam
- Netherlands Organization for the Health Research and Development (ZonMw)
- MaculaFonds [2015-36]
- MRC [MR/K023721/1] Funding Source: UKRI
Ask authors/readers for more resources
Purpose: Genetic and epidemiologic studies have shown that lipid genes and high-density lipoproteins (HDLs) are implicated in age-related macular degeneration (AMD). We studied circulating lipid levels in relationship to AMD in a large European dataset. Design: Pooled analysis of cross-sectional data. Participants: Individuals (N = 30 953) aged 50 years or older participating in the European Eye Epidemiology (E3) consortium and 1530 individuals from the Rotterdam Study with lipid subfraction data. Methods: AMD features were graded on fundus photographs using the Rotterdam classification. Routine blood lipid measurements, genetics, medication, and potential confounders were extracted from the E3 database. In a subgroup of the Rotterdam Study, lipid subfractions were identified by the Nightingale biomarker platform. Random-intercepts mixed-effects models incorporating confounders and study site as a random effect were used to estimate associations. Main Outcome Measures: AMD features and stage; lipid measurements. Results: HDL was associated with an increased risk of AMD (odds ratio [OR], 1.21 per 1-mmol/l increase; 95% confidence interval [CI], 1.14-1.29), whereas triglycerides were associated with a decreased risk (OR, 0.94 per 1-mmol/l increase; 95% CI, 0.91-0.97). Both were associated with drusen size. Higher HDL raised the odds of larger drusen, whereas higher triglycerides decreases the odds. LDL cholesterol reached statistical significance only in the association with early AMD (P = 0.045). Regarding lipid subfractions, the concentration of extra-large HDL particles showed the most prominent association with AMD (OR, 1.24; 95% CI, 1.10-1.40). The cholesteryl ester transfer protein risk variant (rs17231506) for AMD was in line with increased HDL levels (P = 7.7 x 10(-7)), but lipase C risk variants (rs2043085, rs2070895) were associated in an opposite way (P = 1.0 x 10(-6) and P = 1.6 x 10(-4)). Conclusions: Our study suggested that HDL cholesterol is associated with increased risk of AMD and that triglycerides are negatively associated. Both show the strongest association with early AMD and drusen. Extra-large HDL subfractions seem to be drivers in the relationship with AMD, and variants in lipid genes play a more ambiguous role in this association. Whether systemic lipids directly influence AMD or represent lipid metabolism in the retina remains to be answered. (C) 2018 by the American Academy of Ophthalmology
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available