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Role of retinoic acid receptor (RAR) signaling in post-natal male germ cell differentiation

Journal

Publisher

ELSEVIER
DOI: 10.1016/j.bbagrm.2014.05.019

Keywords

Infertility; Meiosis; Nuclear receptor; Rexinoid; Sertoli cell; Testis

Funding

  1. CNRS
  2. INSERM
  3. UdS
  4. Fondation pour la Recherche Medicale (FRM) [DEQ20071210544]
  5. Agence Nationale pour la Recherche (ANR) [09-BLAN-0282, 09-BLAN-0286, 10-BLAN-1239-04]
  6. FRM [FDT20080914176, FDT20110922849]
  7. European Union [331687]
  8. French Ministry of Research and Technology
  9. Association pour la Recherche sur le Cancer
  10. French State fund [ANR-10-LABX-0030-INRT, ANR-10-IDEX-0002-02]

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All-trans retinoic acid (atRA), the active metabolite of vitamin A, plays critical functions in spermatogenesis, a complex, highly organized and regulated process comprising three phases. During the proliferative phase, undifferentiated spermatogonia divide to maintain a stem cell population and expand a progenitor cell population, of which a fraction enters the differentiation pathway yielding primary spermatocytes. During the meiotic phase, primary spermatocytes undergo recombination, segregation and reduction by half of chromosomes to produce haploid round spermatids. During the morphogenetic, post-meiotic phase, spermatids differentiate and elongate to ultimately form spermatozoa. Studies performed during the past 20 years have significantly improved our knowledge on the location of the proteins transducing the atRA signal, on the target genes of atRA and on its mechanism of action. This article is part of a Special Issue entitled: Nuclear receptors in animal development. (C) 2014 Elsevier B.V. All rights reserved.

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