Journal
OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA
Volume 45, Issue 4, Pages 663-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ogc.2018.07.007
Keywords
Depression; Perimenopause; Hormones; Genetics; Psychosocial and health factors
Categories
Funding
- NIH Office of Research on Women's Health [P50 MH099910]
- NIMH [P50 MH099910]
- NIA [AG012546]
- NATIONAL INSTITUTE OF MENTAL HEALTH [P50MH099910] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [U01AG012546] Funding Source: NIH RePORTER
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Vulnerability to depression is increased across the menopause transition and in the early years after the final menstrual period. Clinicians should systematically screen women in this age group; if depressive symptoms or disorder are present, treatment of depression should be initiated. Potential treatments include antidepressants for moderate to severe symptoms, psychotherapy to target psychological and interpersonal factors, and hormone therapy for women with first-onset major depressive disorder or elevated depressive symptoms and at low risk for adverse effects. Behavioral interventions can improve physical activity and sleep patterns.
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