Journal
NUTRITION & METABOLISM
Volume 15, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12986-018-0324-5
Keywords
Calorie restriction; Coffee; Dietary fiber; Red meat; Beta-cell function
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Funding
- DDZ - German Diabetes Center - German Federal Ministry of Health (Berlin, Germany)
- Ministry of Culture and Science of the state North Rhine-Westphalia (Dusseldorf, Germany)
- German Federal Ministry of Education and Research (BMBF)
- Helmholtz Alliance Imaging and Curing Environmental Metabolic Diseases (ICEMED)
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BackgroundHigher dietary intake of fibers and coffee, but lower red meat intake is associated with reduced risk for type 2 diabetes in epidemiological studies. We hypothesized that a calorie-restricted diet, which is high in fiber and coffee, but free of red meat, improves beta-cell function in patients with T2D.MethodsIn a randomized parallel-group pilot trial, obese type 2 diabetes patients were randomly allocated to consume either a diet high in cereal fiber and coffee, but free of red meat (n=17) (L-RISK) or a diet low in fiber, free of coffee but high in red meat (n=20) (H-RISK) for 8weeks. Insulin secretion was assessed from glucagon stimulation tests (GST) and mixed-meal tolerance tests (MMTT) before and after dietary intervention.ResultsBoth diets resulted in comparable reduction of fasting concentrations of insulin (H-RISK -28% vs. L-RISK -32%, bothp<0.01), C-peptide (H-RISK -26% vs. L-RISK -30%, bothp<0.01) and blood glucose (H-RISK -6.8%, p<0.05 vs. L-RISK -10%, p<0.01). Gastric inhibitory peptide (GIP) secretion increased by 24% after 8weeks in the L-RISK only (p<0.01). However, GST and MMTT showed no differences in insulin secretion after intervention.ConclusionsCalorie restriction independent of the intake of fiber, coffee or meat failed to improve beta-cell function, but improved GIP secretion in obese patients with type 2 diabetes.Trial registrationRegistration at Clinicaltrials.gov, Identifier number: NCT01409330, Registered 4 August 2011 - Retrospectively registered.
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