Journal
NUCLEIC ACIDS RESEARCH
Volume 47, Issue D1, Pages D330-D338Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gky1055
Keywords
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Categories
Funding
- National Human Genome Research Institute [U41 HG02273, U41 HG001315, U24 HG002223, U41HG000739, HG 000330, HG 002273, U41HG007822, U41HG002273]
- National Institute of General Medical Sciences [GM064426, GM087371, R01GM080646, P20GM103446, U01GM120953]
- National Institutes of Health [GM089636]
- National Science Foundation [1565146, 1458400]
- EMBL core funds
- UK Medical Research Council [MR/N030117/1]
- Wellcome Trust [108433/Z/15/Z, 104967/Z/14/Z]
- Biotechnology and Biological Sciences Research Council [BB/N00521X/1, BB/N019172/1, BB/L024136/1]
- Gene Regulation Ensemble Effort for the Knowledge Commons (GREEKC) COST Action [CA15205]
- Research Council of Norway [247727]
- British Heart Foundation [RG/13/5/30112]
- Parkinson's UK [G-1307]
- National Institute for Health Research University College London Hospitals Biomedical Research Centre
- European Molecular Biology Laboratory core funds
- National Heart, Lung, and Blood Institute [HL 64541]
- National Eye Institute
- National Human Genome Research Institute
- National Heart, Lung and Blood Institute
- National Institute of Allergy and Infectious Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of General Medical Sciences
- National Institute of Mental Health of the National Institutes of Health [U24HG007822]
- Biotechnology and Biological SciencesResearch Council [BB/M011674/1]
- Swiss Federal Government through the State Secretariat for Education, Research and Innovation (SERI)
- European Molecular Biology Laboratory
- US National Human Genome Research Institute [U24-HG002223]
- UKBiotechnology and Biological Sciences Research Council [BB/K020080]
- Wellcome Trust [108433/Z/15/Z] Funding Source: Wellcome Trust
- BBSRC [BB/L024136/1, BB/N019172/1, BB/N00521X/1] Funding Source: UKRI
- MRC [MR/N030117/1] Funding Source: UKRI
- Direct For Biological Sciences
- Div Of Biological Infrastructure [1565146] Funding Source: National Science Foundation
- Div Of Biological Infrastructure
- Direct For Biological Sciences [1458400] Funding Source: National Science Foundation
Ask authors/readers for more resources
The Gene Ontology resource (GO; http://geneontology.org) provides structured, computable knowledge regarding the functions of genes and gene products. Founded in 1998, GO has become widely adopted in the life sciences, and its contents are under continual improvement, both in quantity and in quality. Here, we report the major developments of the GO resource during the past two years. Each monthly release of the GO resource is now packaged and given a unique identifier (DOI), enabling GO-based analyses on a specific release to be reproduced in the future. The molecular function ontology has been refactored to better represent the overall activities of gene products, with a focus on transcription regulator activities. Quality assurance efforts have been ramped up to address potentially out-of-date or inaccurate annotations. New evidence codes for high-throughput experiments now enable users to filter out annotations obtained from these sources. GO-CAM, a new framework for representing gene function that is more expressive than standard GO annotations, has been released, and users can now explore the growing repository of these models. We also provide the GO ribbon' widget for visualizing GO annotations to a gene; the widget can be easily embedded in any web page.
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