Journal
NUCLEIC ACIDS RESEARCH
Volume 47, Issue D1, Pages D309-D314Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gky1085
Keywords
-
Categories
Funding
- European Union's Horizon 2020 research and innovation programme [686070]
- Ramon y Cajal Programme [RYC2016-20621]
- Consejeria de Educacion, Juventud y Deporte de la Comunidad de Madrid and Fondo Social Europeo [PEJ-2017-AI/TIC-7514]
- FP7 METACARDIS [HEALTH-F4-2012-305312]
- Novo Nordisk Foundation (Copenhagen) [NNF14CC0001]
- European Molecular Biology Laboratory
- BMBF [031A537B]
- Swiss National Science Foundation [31003A-160095]
Ask authors/readers for more resources
eggNOG is a public database of orthology relationships, gene evolutionary histories and functional annotations. Here, we present version 5.0, featuring a major update of the underlying genome sets, which have been expanded to 4445 representative bacteria and 168 archaea derived from 25 038 genomes, as well as 477 eukaryotic organisms and 2502 viral proteomes that were selected for diversity and filtered by genome quality. In total, 4.4M orthologous groups (OGs) distributed across 379 taxonomic levels were computed together with their associated sequence alignments, phylogenies, HMM models and functional descriptors. Precomputed evolutionary analysis provides fine-grained resolution of duplication/speciation events within each OG. Our benchmarks show that, despite doubling the amount of genomes, the quality of orthology assignments and functional annotations (80% coverage) has persisted without significant changes across this update. Finally, we improved eggNOG online services for fast functional annotation and orthology prediction of custom genomics or metagenomics datasets. All precomputed data are publicly available for downloading or via API queries at http://eggnog.embl.de
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available