Social, self, (situational), and affective processes in medial prefrontal cortex (MPFC): Causal, multivariate, and reverse inference evidence

The medial prefrontal cortex (MPFC) has been posited to serve a variety of social, affective, and cognitive functions. These conclusions have largely been driven by forward inference analyses (e.g. GLM fMRI studies and meta-analyses) that indicate where domain-specific tasks tend to produce activity but tell us little about what those regions do. Here, we take a multi-method, multi-domain approach to the functionality of MPFC subdivisions within Brodmann areas 9-11. We consider four methods that each have reverse inference or causal inference value: lesion work, transcranial magnetic stimulation, multivariate pattern analysis, and Neurosynth analyses. The Neurosynth analyses include multi-term reverse inference analyses that compare several domains of interest to one another at once. We examine the evidence supporting structure-function links in five domains: social cognition, self, value, emotional experience, and mental time travel. The evidence is considered for each of three MPFC subdivisions: dorsomedial prefrontal cortex (DMPFC), anteromedial prefrontal cortex (AMPFC), and ventromedial prefrontal cortex (VMPFC). Although there is evidentiary variability across methods, the results suggest that social processes are functionally linked to DMPFC (and somewhat surprisingly in VMPFC), self processes are linked to AMPFC, and affective processes are linked to AMPFC and VMPFC. There is also a relatively non-selective region of VMPFC that may support situational processing, a process key to each domain, but also independent of each.