Journal
NEURON
Volume 100, Issue 5, Pages 1241-+Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2018.11.031
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Funding
- Human Frontier Science Program Postdoctoral Fellowship [LT000769/2015]
- Swiss National Science Foundation Ambizione Grant [PZOOP3_168213]
- Canada Research Chair Grant
- Swiss National Science Foundation [3100330B_163457]
- European Research Council [669157]
- DARPA [HR0011-17-C-0038]
- National Center of Competence in Research Molecular Systems Engineering grant
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Large numbers of brain regions are active during behaviors. A high-resolution, brain-wide activity map could identify brain regions involved in specific behaviors. We have developed functional ultrasound imaging to record whole-brain activity in behaving mice at a resolution of similar to 100 mm. We detected 87 active brain regions during visual stimulation that evoked the optokinetic reflex, a visuomotor behavior that stabilizes the gaze both horizontally and vertically. Using a genetic mouse model of congenital nystagmus incapable of generating the horizontal reflex, we identified a subset of regions whose activity was reflex dependent. By blocking eye motion in control animals, we further separated regions whose activity depended on the reflex's motor output. Remarkably, all reflex-dependent but eye motion-independent regions were located in the thalamus. Our work identifies functional modules of brain regions involved in sensorimotor integration and provides an experimental approach to monitor whole-brain activity of mice in normal and disease states.
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