Journal
NEURON
Volume 100, Issue 3, Pages 579-+Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2018.08.032
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Categories
Funding
- NKFIH postdoctoral fellowship [PD-020/2015, PD-125386]
- Wellcome Trust International Senior Research Fellowship [090915/Z/09/Z]
- International Research Scholar Program of the Howard Hughes Medical Institute [55008740]
- Wellcome Trust/Royal Society Henry Dale Fellowship [098400/Z/12/Z]
- Medical Research Council (MRC) [MC-UP-1201/1]
- Wellcome Trust
- Gatsby Charitable Foundation SWC Fellowship
- Wellcome Trust New Investigator Award [095621/Z/11/Z]
- MTA
- MRC [MC_UP_1201/1] Funding Source: UKRI
- Wellcome Trust [095621/Z/11/Z, 098400/Z/12/Z, 090915/Z/09/Z] Funding Source: Wellcome Trust
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Dendrites integrate inputs nonlinearly, but it is unclear how these nonlinearities contribute to the overall input-output transformation of single neurons. We developed statistically principled methods using a hierarchical cascade of linear-nonlinear subunits (hLN) to model the dynamically evolving somatic response of neurons receiving complex, in vivo-like spatiotemporal synaptic input patterns. We used the hLN to predict the somatic membrane potential of an in vivo-validated detailed biophysical model of a L2/3 pyramidal cell. Linear input integration with a single global dendritic nonlinearity achieved above 90% prediction accuracy. A novel hLN motif, input multiplexing into parallel processing channels, could improve predictions as much as conventionally used additional layers of local nonlinearities. We obtained similar results in two other cell types. This approach provides a data-driven characterization of a key component of cortical circuit computations: the input-output transformation of neurons during in vivo-like conditions.
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