Journal
ACS NANO
Volume 10, Issue 4, Pages 4863-4872Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.6b02058
Keywords
photothermal therapy; ultrasmall; multifunctional; dendrimer; cancer targeting
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Funding
- National Natural Science Foundation of China [21274044, 21207038]
- Basic Research Program of Science and Technology Commission of Shanghai Municipality [14JC1491100]
- Shanghai Pujiang Program [14PJD016]
- Shanghai Chenguang Program [12CG25]
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Ultrasmall and multifunctional nanoparticles are highly desirable for photothermal cancer therapy, but the synthesis of these nanoparticles remains a huge challenge. Here, we used a dendrimer as a template to synthesize ultrasmall photothermal agents and further modified them with multifunctional groups. Dendrimer-encapsulated nanoparticles (DENPs) including copper sulfide, platinum, and palladium nanoparticles possessed a sub-5 nm size and exhibited an excellent photo thermal effect. DENPs were further modified with TAT or RGD peptides to facilitate their cellular uptake and targeting delivery to tumors. They were also decorated with fluorescent probes for real-time imaging and tracking of the particles' distribution. The in vivo study revealed RGD-modified DENPs efficiently reduced the tumor growth upon near-infrared irradiation. In all, our study provides a facile and flexible scaffold to prepare ultrasmall and multifunctional photothermal agents.
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