Journal
ACS NANO
Volume 10, Issue 1, Pages 1060-1066Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.5b06383
Keywords
bioimaging; core/active shell structure; dye-sensitizing; near-infrared; optogenetics; upconversion nanoparticles
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Funding
- China Scholarship Council (CSC)
- Worcester Foundation Mel Cutler Award
- National Institutes of Health [R01MH103133]
- Human Frontier Science Program [RGY-0090/2014]
- U.S. Department of Energy [DE-AC02-05CH11231]
- U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences Early Career Research Program [67037]
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH103133] Funding Source: NIH RePORTER
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Near-infrared (NIR) dye-sensitized upconversion nanoparticles (UCNPs) can broaden the absorption range and boost upconversion efficiency of UCNPs. Here, we achieved significantly enhanced up conversion luminescence in dye-sensitized core/active shell UCNPs via the doping of ytterbium ions (Yb3+) in the UCNP shell, which bridged the energy transfer from the dye to the UCNP core. As a result, we synergized the two most practical upconversion booster effectors (dye-sensitizing and core/shell enhancement) to amplify upconversion efficiency. We demonstrated two biomedical applications using these UCNPs. By using dye-sensitized core/active shell UCNP embedded poly(methyl methacrylate) polymer implantable systems, we successfully shifted the optogenetic neuron excitation window to a biocompatible and deep tissue penetrable 800 nm wavelength. Furthermore, UCNPs were water-solubilized with Pluronic F127 with high upconversion efficiency and can be imaged in a mouse model.
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