Journal
ACS NANO
Volume 10, Issue 3, Pages 3622-3629Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.5b08103
Keywords
graphene quantum dots; fluorometric biosensing; photoluminescence quenching; metabolite detection
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Funding
- Ministry of Education (Singapore) [MOE2014-T2-1-003]
- CBRG grant [NMRC/CBRG/0070/2014]
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Graphene quantum dots (GQDs) are emerging fluorescence reporters attractive for optical sensing, owing to their high photostability, highly tunable photoluminescence, molecular size, atomically thin structure, bio compatibility, and ease of functionalization. Herein, we present a fluorometric sensing platform based on tyramine-functionalized GQDs, which is able to detect a spectrum of metabolites with high sensitivity and specificity. Furthermore, multiparametric blood analysis (glucose, cholesterol, L-lactate, and xanthine) is demonstrated. This convenient metabolite profiling technique could be instrumental for diagnosis, study, and management of metabolic disorders and associated diseases, such as diabetes, obesity, lactic acidosis, gout, and hypertension.
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