Journal
NEUROLOGIC CLINICS
Volume 36, Issue 4, Pages 687-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ncl.2018.07.004
Keywords
Neuroinfectious diseases; Meningoencephalitis; Meningitis; Encephalitis; Metagenomic next-generation sequencing; Neurosyphilis; Neurocysticercosis; Neuroborreliosis
Categories
Funding
- NINDS NIH HHS [K08 NS096117] Funding Source: Medline
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Neuro-Infectious diseases continue to cause morbidity and mortality worldwide, with many emerging or reemerging infections resulting in neurologic sequelae. Careful clinical evaluation coupled with appropriate laboratory investigations still forms the bedrock for making the correct etiologic diagnosis and implementing appropriate management. The treating physician needs to understand the individual test characteristics of each of the many conventional candidate-based diagnostics: culture, pathogen-specific polymerase chain reaction, antigen, antibody tests, used to diagnose the whole array of neuroinvasive infections. In addition, there is a growing need for more comprehensive, agnostic testing modalities that can identify a diversity of infections with a single assay.
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