Journal
NEUROIMAGE
Volume 185, Issue -, Pages 490-512Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2018.10.044
Keywords
Aging; Response inhibition; Neural oscillations; Functional connectivity; Phase synchronization; Transcranial alternating current stimulation (tACS)
Funding
- Dementia Australia Research Foundation [711-1641]
- Australia-Germany Joint Research Co-operation (DAAD) [57384703]
- German Ministry of Research and Education [01EE1403C, 01GQ1424E]
- Deutsche Forschungsgemeinschaft -Germany [SFB 1280]
- Australian Research Council's Discovery Program [FT150100406]
- Australian Research Council [FT150100406] Funding Source: Australian Research Council
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Response inhibition, the ability to withhold a dominant and prepotent response following a change in circumstance or sensory stimuli, declines with advancing age. While non-invasive brain stimulation (NiBS) has shown promise in alleviating some cognitive and motor functions in healthy older individuals, NiBS research focusing on response inhibition has mostly been conducted on younger adults. These extant studies have primarily focused on modulating the activity of distinct neural regions known to be critical for response inhibition, including the right inferior frontal gyrus (rIFG) and the pre-supplementary motor area (pre-SMA). However, given that changes in structural and functional connectivity have been associated with healthy aging, this review proposes that NiBS protocols aimed at modulating the functional connectivity between the rIFG and pre-SMA may be the most efficacious approach to investigate-and perhaps even alleviate-age-related deficits in inhibitory control.
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