Journal
ACS NANO
Volume 10, Issue 12, Pages 11145-11155Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.6b06067
Keywords
multimodal imaging; radiophotothermal therapy; bismuth selenide nanodots; ultrasmall; bovine serum albumin
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Funding
- National Natural Science Foundation of China [81471657, 81527901]
- 1000 Plan for Young Talents
- Jiangsu Specially Appointed Professorship
- Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection
- Priority Academic Development Program of Jiangsu Higher Education Institutions (PAPD)
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Sub-3 nm ultrasmall Bi2Se3 nanodots stabilized with bovine serum albumin were successfully synthesized through a reaction of hydroxyethylthioselenide with bismuth chloride in aqueous solution under ambient conditions. These nanodots exhibit a high photothermal conversion efficiency (eta = 50.7%) due to their strong broad absorbance in the near-infrared (NIR) window and serve as a nanotheranostic agent for photoacoustic imaging and photothermal cancer therapy. In addition, they also display radioenhancement with a ratio of 6% due to their sensitivity to X-rays, which makes them a potential sensitizer for radiotherapy. These nanodots were also labled with radioactive Tc-99m for quantification of their biodistribution by single-photon-emission computed tomography (SPECT)/computed tomography (CT) imaging. Our work demonstrates the potential of ultrasmall Bi2Se3 nanodots in multimodal imaging-guided synergetic radiophotothermal therapy of cancer.
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