Journal
ACS NANO
Volume 10, Issue 11, Pages 9809-9815Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.6b05276
Keywords
SERS; DNA Origami; single molecule; plasmonic heating
Categories
Funding
- Volkswagen Foundation
- ERC
- DFG [SFB 1032]
- Engineering and Physical Sciences Research Council [GR/A10274/01] Funding Source: researchfish
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DNA origami is a powerful approach for assembling plasmonic nanoparticle dimers and Raman dyes with high yields and excellent positioning control. Here we show how optothermal-induced shrinking of a DNA origami template can be employed to control the gap sizes between two 40 nm gold nanoparticles in a range from 1 to 2 nm. The high field confinement achieved with this optothermal approach was demonstrated by detection of surface enhanced Raman spectroscopy (SERS) signals from single molecules that are precisely placed within the DNA origami template that spans the nanoparticle gap. By comparing the SERS intensity with respect to the field enhancement in the plasmonic hot-spot region, we found good agreement between measurement and theory. Our straightforward approach for the fabrication of addressable plasmonic nanosensors by DNA origami demonstrates a path toward future sensing applications with single-molecule resolution.
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