Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 122, Issue -, Pages 139-143Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2018.11.016
Keywords
Glioma; Glioblastoma; Astrocyte; Epithelial-to-mesenchymal transition; EMT
Categories
Funding
- Coordenacao de Aperfeicoamento de Pessoal de NIvel Superior (CAPES, Brazil)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil)
- CAPES [PROCAD - 158819]
- International Centre for Genetic Engineering and Biotechnology (ICGEB) [405231/2015-6 MCTI/CNPq-ICGEB]
- Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS, RS, Brazil) [Pronex 16/2551-0000473-0]
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The concept of the epithelial-to-mesenchymal transition (EMT) in epithelial cells has accelerated our understanding about cancer spreading. Fortunately, much of this information has been able to be extrapolated to non-epithelial cancers, such as glioblastoma (GBM). Interestingly, reactive astrocytes, which are present in the tumor edge in association with glioma cells, might also undergo EMT-like under stimuli of GBM cells. As result, the positive feedback of reactive astrocytes and glioma cells, could act to promote cancer progression making use of the dynamism of the mesenchymal phenotype. Nonetheless, the interpretation of data regarding EMT-like in GBM and astrocytes requires prudence, mainly because the program of EMT in epithelial tumors may not necessarily be the same as those in gliomas and astrocytes.
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