Journal
NEUROBIOLOGY OF AGING
Volume 76, Issue -, Pages 162-165Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2018.12.014
Keywords
Klotho; KL-VS; Cognition; Episodic memory; amyloid-beta; Preclinical; Alzheimer's disease
Categories
Funding
- Commonwealth Scientific and Industrial Research Organisation, Australia
- Edith Cowan University, Australia
- Mental Health Research institute (MHRI)
- National Ageing Research Institute (NARI)
- Austin Health
- CogState Ltd
- National Health and Medical Research Council, Australia
- Dementia Collaborative Research Centres program [DCRC2]
- Science and Industry Endowment Fund, Australia
- Cooperative Research Centre (CRC) for Mental Health through CRC Program, an Australian Government Initiative [20100104]
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The longevity gene Klotho (KL), specifically the functional KL-VS variant, has previously been associated with cognition and rates of cognitive decline. This study aimed to determine whether KL-VS associations with cognition were observable in preclinical Alzheimer's disease (AD). The study also aimed to determine whether there was a combined influence of KL-VS, neocortical amyloid-beta (A beta) burden, and carriage of the apolipoprotein E (APOE) epsilon 4 allele on cognitive decline. This study involved 581 A beta-imaged, cognitively normal older adults, enrolled in the Australian Imaging, Biomarkers and Lifestyle Study of Aging. Linear mixed effects models revealed no significant associations between KL-VS and cognitive decline independently or in combination with A beta burden and APOE epsilon 4 genotype. Overall, previous associations reported between KL-VS and cognitive decline are not observed at the preclinical stages of AD. Furthermore, the results do not support the hypothesis that KL-VS has a modifying effect on A beta burden and APOE epsilon 4-driven cognitive decline in preclinical AD. (C) 2019 Elsevier Inc. All rights reserved.
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