Journal
NATURE REVIEWS NEUROSCIENCE
Volume 20, Issue 1, Pages 34-48Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41583-018-0091-3
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Funding
- Heart and Stroke Foundation of Canada (HSFC)
- Canadian Partnership for Stroke Recovery
- Parkinson's Research Consortium
- Canadian Institutes of Health Research
- Brain Canada/Krembil Foundation
- HSFC
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Emerging evidence now indicates that mitochondria are central regulators of neural stem cell (NSC) fate decisions and are crucial for both neurodevelopment and adult neurogenesis, which in turn contribute to cognitive processes in the mature brain. Inherited mutations and accumulated damage to mitochondria over the course of ageing serve as key factors underlying cognitive defects in neurodevelopmental disorders and neurodegenerative diseases, respectively. In this Review, we explore the recent findings that implicate mitochondria as crucial regulators of NSC function and cognition. In this respect, mitochondria may serve as targets for stem-cell-based therapies and interventions for cognitive defects.
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